Sodium Hydroxide → 3-Methylindan-1-one oxime
반응식
[CH3:1][CH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=O)[CH2:3]1.Cl.[NH2:13][OH:14].[OH-].[Na+]>CO.O>[CH3:1][CH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[N:13][OH:14])[CH2:3]1참가 물질
6
반응 조건
- 온도
- 80 °C
실험 절차
To a solution of 3-methylindan-1-one (221 mg, 1.51 mmol) and hydroxylamine hydrochloride (295 mg, 4.25 mmol) in MeOH (4.00 mL) was added a solution of NaOH (200 mg, 5.00 mmol) in H2O (2.00 mL) and the mixture was stirred at 80° C. for 2 h. The cooled reaction was concentrated in vacuo to remove most of the MeOH, and the residue was partitioned between DCM and H2O. The organic layer was concentrated in vacuo to afford the title compound as a waxy solid (232 mg, 95%). LC/MS: Rt=1.51 min, ES+ 162 (AA standard).
후처리
- customThe cooled reaction
- concentrationwas concentrated in vacuo
- customto remove most of the MeOH
- customthe residue was partitioned between DCM and H2O
- concentrationThe organic layer was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-4b3ece9ae9484bfd8bffe453d0cc7e8c
- 출처 데이터셋
- uspto-grants-2013_07
- 특허 번호
- US08481550B2
반응 노트
불러오는 중…