Hydrochloric Acid → HCID 59496679, 화합물

HRID 449368노트

반응식

HRID 449368 반응식
O.[OH-].[Li+].[NH2:4][C:5]1[N:10]=[C:9]([C:11]2[CH:20]=[C:19]3[C:14]([CH2:15][CH2:16][N:17]([C:21]([NH:23][C@@H:24]([CH2:29][C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)[C:25]([O:27]C)=[O:26])=[O:22])[CH2:18]3)=[CH:13][CH:12]=2)[CH:8]=[C:7]([N:36]2[CH2:41][CH2:40][N:39]([CH3:42])[CH2:38][CH2:37]2)[N:6]=1.Cl.[Li+].[Cl-]>CO.O.O1CCOCC1>[NH2:4][C:5]1[N:10]=[C:9]([C:11]2[CH:20]=[C:19]3[C:14]([CH2:15][CH2:16][N:17]([C:21]([NH:23][C@@H:24]([CH2:29][C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)[C:25]([OH:27])=[O:26])=[O:22])[CH2:18]3)=[CH:13][CH:12]=2)[CH:8]=[C:7]([N:36]2[CH2:37][CH2:38][N:39]([CH3:42])[CH2:40][CH2:41]2)[N:6]=1

참가 물질

8

반응물 4

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 433294Lithium ChlorideHCID 86645777HCID 86645777, 화합물

생성물 1

HCID 59496679HCID 59496679, 화합물

시약·촉매·용매 3

HCID 887Methanol용매HCID 962Water용매HCID 312751,4-Dioxane용매

실험 절차

Lithium hydroxide monohydrate (7.1 mg, 0.17 mmol) was added to a mixture of methyl (2S)-2-({[7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}amino)-3-phenylpropanoate (30 mg, 0.057 mmol) in methanol (0.6 mL) and water (0.2 mL). The reaction mixture was stirred at r.t. overnight, and adjusted with 4N HCl in 1,4-dioxane to pH=5. The volatiles were removed under reduced pressure to afford the product which contaminated with LiCl and was directly used for next step reaction without further purification.

후처리

  1. customThe volatiles were removed under reduced pressure
  2. customto afford the product which
  3. customwas directly used for next step reaction without further purification

출처 및 근거

ORD 기록
ord-15d594a2b4904990acfa57080da7aa59
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08481732B2

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