p-Aminoacetophenone → 4-Amino-alpha-methylbenzenemethanol

HRID 450038

반응식

HRID 450038 반응식
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([NH2:10])=[CH:6][CH:5]=1)=[O:3].[BH4-].[Na+]>CO>[NH2:10][C:7]1[CH:8]=[CH:9][C:4]([CH:2]([OH:3])[CH3:1])=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 7468p-AminoacetophenoneHCID 4311764Sodium borohydride

생성물 1

HCID 857534-Amino-alpha-methylbenzenemethanol수율 80%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 4-amino acetophenone (0.5 g, 3.7 mmol) in methanol (10 ml), was added sodium borohydride (0.27 g, 7.4 mmol, 2 eq) at 0° C. The reaction mixture was stirred for 3 hr at room temperature. The solvent was evaporated and water was added. The compound was extracted with ethyl acetate, then the organic layer was dried over anhydrous sodium sulfate, filtered and concentrated to dryness to yield pure 1-(4-amino-phenyl)-ethanol (0.4 g, 80%).

후처리

  1. customThe solvent was evaporated
  2. additionwater was added
  3. extractionThe compound was extracted with ethyl acetate
  4. dry with materialthe organic layer was dried over anhydrous sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-cb06a862c1374d518862cadc08beb88f
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08486962B2

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