Bromine → HCID 67334263, 화합물
반응식
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([NH2:10])=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[Br:11]Br.S([O-])([O-])(=O)=S.[Na+].[Na+]>C(Cl)(Cl)Cl>[Br:11][C:6]1[C:7]([NH2:10])=[N:8][CH:9]=[C:4]([CH:1]2[CH2:3][CH2:2]2)[CH:5]=1참가 물질
5
실험 절차
To a solution of 5-cyclopropyl-pyridin-2-ylamine (1.1 g, 8.19 mmol) in dry chloroform (100 mL) was added bromine (0.42 mL, 8.2 mmol) in chloroform (11 mL) at room temperature and stirred for 18 hours. An aqueous solution of sodium thiosulfate was added, the aqueous phase was extracted with dichloromethane, the combined organic phases were dried over sodium sulfate, the solvent was evaporated and the residue purified by silica gel chromatography using ethyl acetate/hexane as eluent. The title compound was obtained as light yellow oil (1.0 g, 57%).
후처리
- extractionthe aqueous phase was extracted with dichloromethane
- dry with materialthe combined organic phases were dried over sodium sulfate
- customthe solvent was evaporated
- customthe residue purified by silica gel chromatography
출처 및 근거
- ORD 기록
- ord-a89899d0bc4e43eaa31002532f897ecd
- 출처 데이터셋
- uspto-grants-2013_07
- 특허 번호
- US08486967B2
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