Hydrochloric Acid → HCID 86596673, 화합물

HRID 451617

반응식

HRID 451617 반응식
[C:1]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[C:10](=[O:14])[CH2:9][CH2:8]2)([CH3:4])([CH3:3])[CH3:2].[N:15](OCCC(C)C)=[O:16].Cl>CO>[C:1]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[C:10](=[O:14])[C:9](=[N:15][OH:16])[CH2:8]2)([CH3:4])([CH3:2])[CH3:3]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 8053Isoamyl NitriteHCID 110305765-Tert-butyl-2,3-dihydroinden-1-one

생성물 1

HCID 86596673HCID 86596673, 화합물수율 137.7%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

5-tert-butyl-indan-1-one (9.39 g, 39 mmol) was dissolved in 150 ml methanol. Isoamyl nitrite (5 g, 43 mmol) and conc. HCl (5 ml) were added, and the reaction stirred at ambient temperature for 44 hours. The solvents were removed under vacuum to give 11.67 grams of crude product which was used without further purification. 1H NMR (300 MHz, CDCl3) 7.82 (d, 1H), 7.51 (s, 1H), 7.49 (d, 1H), 3.83 (s, 2H), 3.50 (s, 1H, OH) 1.34 (s, 9H). MS (CSI) m/e 218 (M+H)+, 235 (m+NH4)+

후처리

  1. customThe solvents were removed under vacuum

출처 및 근거

ORD 기록
ord-33f1e9d4c2fa409d9d3d76d67b539f6d
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08487116B2

연결된 노트

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