Hydrochloric Acid → 1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid
반응식
C([N:4]1[C:8]2[N:9]=[CH:10][CH:11]=C(C#N)[C:7]=2[CH:6]=[CH:5]1)(=O)C.[OH-:15].[Na+].[CH2:17]([OH:19])[CH3:18].Cl>O>[NH:4]1[C:8]2[N:9]=[CH:10][CH:11]=[C:18]([C:17]([OH:15])=[O:19])[C:7]=2[CH:6]=[CH:5]1참가 물질
6
반응 조건
- 온도
- 90 °C
실험 절차
A mixture of 1-acetyl-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile (1.80 g, 11.10 mmol), 2 M aqueous sodium hydroxide solution (25 mL) and ethanol (25 mL) was stirred at 90° C. for 16 hr. The reaction mixture was neutralized with hydrochloric acid and diluted with water. The precipitate was collected by filtration, and washed with water and diethyl ether to give the title compound (1.51 g, yield 84%) as pale-yellow crystals.
후처리
- filtrationThe precipitate was collected by filtration
- washwashed with water and diethyl ether
출처 및 근거
- ORD 기록
- ord-0225558ae596489fab4eb4960642631b
- 출처 데이터셋
- uspto-grants-2013_07
- 특허 번호
- US08492378B2
반응 노트
불러오는 중…