Hydrazine hydrate (1:1) → 3-[3-(Trifluoromethoxy)phenyl]-1-benzofuran-5-carbohydrazide

HRID 452805

반응식

HRID 452805 반응식
[F:1][C:2]([F:24])([F:23])[O:3][C:4]1[CH:5]=[C:6]([C:10]2[C:14]3[CH:15]=[C:16]([C:19](OC)=[O:20])[CH:17]=[CH:18][C:13]=3[O:12][CH:11]=2)[CH:7]=[CH:8][CH:9]=1.O.[NH2:26][NH2:27]>C(O)C>[F:1][C:2]([F:24])([F:23])[O:3][C:4]1[CH:5]=[C:6]([C:10]2[C:14]3[CH:15]=[C:16]([C:19]([NH:26][NH2:27])=[O:20])[CH:17]=[CH:18][C:13]=3[O:12][CH:11]=2)[CH:7]=[CH:8][CH:9]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 68664542Methyl 3-[3-(trifluoromethoxy)phenyl]-1-benzofuran-5-carboxylate

생성물 1

HCID 686643883-[3-(Trifluoromethoxy)phenyl]-1-benzofuran-5-carbohydrazide

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of methyl 3-[3-(trifluoromethoxy)phenyl]-1-benzofuran-5-carboxylate (6.80 g, 20.2 mmol) and hydrazine monohydrate (9.92 mL, 202.2 mmol) in ethanol (70 mL) was heated under reflux overnight. After cooling, the precipitate was collected by filtration to give 3-[3-(trifluoromethoxy)phenyl]-1-benzofuran-5-carbohydrazide.

후처리

  1. temperatureunder reflux overnight
  2. temperatureAfter cooling
  3. filtrationthe precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-56e45ac22a3f4ebeb9cfd5ed9852e527
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08492378B2

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