Phosphorus oxychloride → 5-[1-(Trifluoromethyl)cyclobutyl]-1,3,4-thiadiazol-2-amine

반응식

[F:1][C:2]([F:11])([F:10])[C:3]1([C:7](O)=O)[CH2:6][CH2:5][CH2:4]1.[NH2:12][NH:13][C:14]([NH2:16])=[S:15].P(Cl)(Cl)(Cl)=O>>[F:1][C:2]([F:11])([F:10])[C:3]1([C:7]2[S:15][C:14]([NH2:16])=[N:13][N:12]=2)[CH2:6][CH2:5][CH2:4]1

참가 물질

반응물 3

HCID 24813Phosphorus oxychloride

HCID 2723789Thiosemicarbazide

HCID 27828381-(Trifluoromethyl)cyclobutanecarboxylic acid

생성물 1

HCID 675457935-[1-(Trifluoromethyl)cyclobutyl]-1,3,4-thiadiazol-2-amine

실험 절차

Commercially available, 1-(trifluoromethyl)cyclobutanecarboxylic acid (Oakwood), thiosemicarbazide (Aldrich) and phosphorus oxychloride (Aldrich) were processed as described for Example 1A to obtain the title compound. MS (ESI+) m/z 224 (M+H)+.

출처 및 근거

ORD 기록: ord-7d491b2187d14304abb08b0e2a1e130d
출처 데이터셋: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08492371B2

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