Hydrochloric Acid → Metformin Hydrochloride
반응식
[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[ClH:10]>CC(C)=O>[CH3:1][N:2]([C:4]([N:6]=[C:7]([NH2:9])[NH2:8])=[NH:5])[CH3:3].[ClH:10]참가 물질
4
실험 절차
500 mg of metformin free base was dissolved in 30 Ml of acetone, and then 280 Ml of concentrated hydrochloric acid was added, and stirred for 2 hours at room temperature. The resulting crystal was filtered and washed with acetone, and then dried with heated air at 70° C. to obtain 490 mg of metformin hydrochloride (yield: 76.4%).
후처리
- filtrationThe resulting crystal was filtered
- washwashed with acetone
- customdried
- temperaturewith heated air at 70° C.
출처 및 근거
- ORD 기록
- ord-bb7f28c0f0144c43ad84ff9519be4688
- 출처 데이터셋
- uspto-grants-2013_09
- 특허 번호
- US08541474B2
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