Hydrochloric Acid → HCID 59394182, 화합물
반응식
[CH3:1][C:2]1([C:5](=O)[CH2:6][C:7]#[N:8])[CH2:4][CH2:3]1.Cl.[CH3:11][NH:12][NH2:13]>CCO.O1CCOCC1>[CH3:11][N:12]1[C:5]([C:2]2([CH3:1])[CH2:4][CH2:3]2)=[CH:6][C:7]([NH2:8])=[N:13]1참가 물질
6
실험 절차
To a solution of 3-(1-methyl-cyclopropyl)-3-oxo-propionitrile (1.0 g, 8.1 mmol) in EtOH (10 mL) is added 4N HCl in Dioxane (10 mL). The mixture is stirred at room temperature for 16 hour. Concentrated under reduced pressure, the residue is dissolved in MeOH (40 mL) and treated with methylhydrazine (0.56 g, 12.2 mmol). The mixture is heated at 80° C. for 16 h. The solution is then concentrated in vacuo and the residue is purified by HPLC give product. MS (ESI) m/z 152.3 (M+1).
후처리
- concentrationConcentrated under reduced pressure
- dissolutionthe residue is dissolved in MeOH (40 mL)
- temperatureThe mixture is heated at 80° C. for 16 h
- concentrationThe solution is then concentrated in vacuo
- customthe residue is purified by HPLC
- customgive product
출처 및 근거
- ORD 기록
- ord-8c4028cdf22742c79107756cc44bb51d
- 출처 데이터셋
- uspto-grants-2013_07
- 특허 번호
- US08492393B2
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