Hydrochloric Acid → Hydrochloric Acid

HRID 455351노트

반응식

HRID 455351 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]2[C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=3[CH2:13][C:2]=12.[ClH:14]>O=[Pt]=O.C(O)C>[NH:1]1[CH2:6][CH2:5][CH2:4][C@@H:3]2[C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=3[CH2:13][C@H:2]12.[ClH:14]

참가 물질

6

반응물 2

HCID 313Hydrochloric AcidHCID 12226515Azafluorene

생성물 2

HCID 313Hydrochloric AcidHCID 58123900cis-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매2회HCID 702Ethanol용매

실험 절차

A mixture of 9H-indeno[2,1-b]pyridine (0.20 g), PtO2 (70 mg), concentrated aqueous hydrochloric acid (0.1 mL), and ethanol (10 mL) is shaken under hydrogen atmosphere (2 bar) at room temperature for 16 h (in case the transformation is not complete after this time another portion of PtO2 (30 mg) is added and shaking under hydrogen is continued until complete). The catalyst is separated by filtration and the solvent is evaporated to give the crude title compound as its hydrochloric acid salt that is used without further purification. Yield: 0.25 g (crude); Mass spectrum (ESI+): m/z=174 [M+H]+.

후처리

  1. additionis added
  2. stirringshaking under hydrogen
  3. customThe catalyst is separated by filtration
  4. customthe solvent is evaporated

출처 및 근거

ORD 기록
ord-a291dfe5e6b84b33b800681e91238d5f
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08497281B2

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