Sulfuric Acid → 5-(2-Benzylaminopropoxy)salicylamide

HRID 4554

반응식

HRID 4554 반응식
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(=O)(=O)(O)O.O=[C:15]([CH3:28])[CH2:16][O:17][C:18]1[CH:26]=[C:22]([C:23]([NH2:25])=[O:24])[C:21]([OH:27])=[CH:20][CH:19]=1.[H][H]>CO.[Pt]>[CH2:1]([NH:8][CH:15]([CH3:28])[CH2:16][O:17][C:18]1[CH:26]=[C:22]([C:23]([NH2:25])=[O:24])[C:21]([OH:27])=[CH:20][CH:19]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

7

반응물 4

HCID 1118Sulfuric AcidHCID 7504BenzylamineHCID 137543335-(2-Oxopropoxy)salicylamideHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 137543345-(2-Benzylaminopropoxy)salicylamide

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 887Methanol용매

실험 절차

55 g of benzylamine and 1.25 g of conc. sulfuric acid are added to a solution of 104.5 g of 5-(2-oxo-propoxy)salicylamide in 1000 ml of methanol, and the mixture is hydrogenated, in the presence of 3.0 g of a Pt/C catalyst under normal conditions until 1 equivalent of hydrogen has been absorbed. The catalyst is filtered off, and the solution is then stirred up with about 10 g of pulverised calcium carbonate; the mixture is again filtered, and concentrated by evaporation. The oil remaining behind crystallises from isopropanol. Repeated recrystallisation from isopropanol yields 5-[2-(benzylamino)-propoxy]-salicylamide, m.p. 102°-104°.

후처리

  1. customhas been absorbed
  2. filtrationThe catalyst is filtered off
  3. filtrationthe mixture is again filtered
  4. concentrationconcentrated by evaporation
  5. custombehind crystallises from isopropanol
  6. customrecrystallisation from isopropanol

출처 및 근거

ORD 기록
ord-fd0ebe5400be4198acdf81230619e204
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04727067

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