Dimethyl Sulfoxide → 2,2-Diphenyl-4-oxo-butyric acid methyl ester

HRID 455904

반응식

HRID 455904 반응식
[CH3:1][O:2][C:3](=[O:20])[C:4]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH2:5][CH2:6]Br.C[N+]([O-:25])(C)C.CS(C)=O>>[CH3:1][O:2][C:3](=[O:20])[C:4]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH2:5][CH:6]=[O:25]

참가 물질

4

반응물 3

HCID 679Dimethyl SulfoxideHCID 1145Trimethylamine oxideHCID 22624494Methyl 4-bromo-2,2-diphenylbutyrate

생성물 1

HCID 866311002,2-Diphenyl-4-oxo-butyric acid methyl ester

실험 절차

A mixture of 4-bromo-2,2-diphenyl-butyric acid methyl ester (0.10 g, 0.300 mmol) and trimethylamine N-oxide (0.09 g, 1.2 mmol) in dimethyl sulfoxide (0.5 mL, 7 mmol) was stirred overnight at room temperature. The reaction was quenched with cold brine. The crude product was extracted three times with dichloromethane, dried over a bed of Na2SO4, filtered, and concentrated to dryness to provide crude title compound which was used without further purification.

후처리

  1. customThe reaction was quenched with cold brine
  2. extractionThe crude product was extracted three times with dichloromethane
  3. dry with materialdried over a bed of Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-a9dddbb5a61f40d499aaf9d7748618ce
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08497287B2

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