Nitrogen → 1-(2-Bromoethoxy)-2,4-difluorobenzene

HRID 456424노트

반응식

HRID 456424 반응식
[F:1][C:2]1[CH:11]=[C:10]([F:12])[CH:9]=[CH:8][C:3]=1[O:4][CH2:5][CH2:6]O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:33].N#N>C(Cl)Cl.CCOC(C)=O>[Br:33][CH2:6][CH2:5][O:4][C:3]1[CH:8]=[CH:9][C:10]([F:12])=[CH:11][C:2]=1[F:1]

참가 물질

7

반응물 4

HCID 947NitrogenHCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 18437003Ethanol, 2-(2,4-difluorophenoxy)-

생성물 1

HCID 232942611-(2-Bromoethoxy)-2,4-difluorobenzene

시약·촉매·용매 2

HCID 6344Dichloromethane용매2회HCID 8857Ethyl Acetate용매

실험 절차

To a cool solution 2-(2,4-difluoro-phenoxy)-ethanol (0.48 g, 2.77 mmol.) in CH2Cl2 (15 ml), triphenyl phosphine (1.3 g, 5 mmol)) was added. Carbon tetrabromide (1.65 g, 5 mmol.) in CH2Cl2 (3 ml) was added to the solution dropwise under N2. The solution was stirred for 30 minutes. EtOAc was added, then the solvent was evaporated under reduced pressure.

후처리

  1. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-d2aed284c51e47ada2a87d9c5beb07e7
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07186726B2

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