[NH:1]1[CH:5]=[CH:4][CH:3]=[CH:2]1.[Cl:6][C:7]1[N:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:8]=1[C:9](Cl)=[O:10]>C(Cl)Cl.O.[Ti](Cl)(Cl)(Cl)Cl>[Cl:6][C:7]1[C:8]([C:9]([C:2]2[NH:1][CH:5]=[CH:4][CH:3]=2)=[O:10])=[CH:12][CH:13]=[C:14]([Cl:16])[N:15]=1.[Cl:6][C:7]1[C:8]([C:9]([C:3]2[CH:4]=[CH:5][NH:1][CH:2]=2)=[O:10])=[CH:12][CH:13]=[C:14]([Cl:16])[N:15]=1Titanium (IV) chloride in DCM (10 mL) was added dropwise to a mixture of pyrrole (4 g) and 2,6-dichloro-nicotinoyl chloride (6 g) in DCM (150 mL) at 0° C. The mixture was then stirred at room temperature for 30 mins. The reaction was diluted with water, washed with water (200 mL), 2N NaOH (50 mL) and brine, dried and concentrated. The residue was purified on a silica gel column to give 1.8 g of (2,6-dichloro-pyridin-3-yl)-(1H-pyrrol-2-yl)-methanone and 380 mg of (2,6-dichloro-pyridin-3-yl)-(1H-pyrrol-3-yl)-methanone.
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