1,4-Cyclohexanedimethanamine → N'-[4-(aminomethyl)cyclohexyl]methyl-N,N-dimethylsulfamide

HRID 457675

반응식

HRID 457675 반응식
[CH3:1][N:2]([CH3:7])[S:3](Cl)(=[O:5])=[O:4].[NH2:8][CH2:9][CH:10]1[CH2:15][CH2:14][CH:13]([CH2:16][NH2:17])[CH2:12][CH2:11]1.C(N(C(C)C)CC)(C)C>ClCCl>[NH2:8][CH2:9][CH:10]1[CH2:15][CH2:14][CH:13]([CH2:16][NH:17][S:3]([N:2]([CH3:7])[CH3:1])(=[O:5])=[O:4])[CH2:12][CH2:11]1

참가 물질

5

반응물 3

HCID 173541,4-CyclohexanedimethanamineHCID 81531DiisopropylethylamineHCID 83372Dimethylsulphamoyl chloride

생성물 1

HCID 22254077N'-[4-(aminomethyl)cyclohexyl]methyl-N,N-dimethylsulfamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Dimethylsulfamoyl chloride (one mol-equivalent, ClSO2N(CH3)2) was added to a stirred solution of 1,4-bis-aminomethylcyclohexane (3 mol-equivalents) and diisopropylethylamine (1 mol-equivalent) in dichloromethane at 0° C. The reaction mixture was stirred at room temperature for 24 hours, concentrated under reduced pressure and chromatographed (silica) to give the desired product as viscous oils. (Scheme 1A).

후처리

  1. concentrationconcentrated under reduced pressure
  2. customchromatographed (silica)

출처 및 근거

ORD 기록
ord-5e70ce1d4c6c492c8f28d8f2334634c4
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07189720B2

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