Carbonyl bromide → HCID 22254060, 화합물

HRID 457682

반응식

HRID 457682 반응식
[NH2:1][C:2]([NH2:4])=[S:3].[CH:5]([C:8]([NH:10][CH:11]1[CH2:16][CH2:15][CH:14](N(C)C(N)=S)[CH2:13][CH2:12]1)=[O:9])([CH3:7])[CH3:6].Br[C:23](Br)=O.C(N(C(C)C)CC)(C)C>CCO>[CH:5]([C:8]([NH:10][CH:11]1[CH2:16][CH2:15][CH:14]([CH2:23][NH:1][C:2]([NH2:4])=[S:3])[CH2:13][CH2:12]1)=[O:9])([CH3:7])[CH3:6]

참가 물질

6

반응물 4

HCID 79057Carbonyl bromideHCID 81531DiisopropylethylamineHCID 2723790ThioureaHCID 17946834HCID 17946834, 화합물

생성물 1

HCID 22254060HCID 22254060, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A thiourea such as N-[4-(isopropylformylamino)cyclohexyl]-methylthiourea (0.029 mmol, 1 equivalent), a bromoketone (0.044 mmol, 1.5 equivalent) and 2 equivalents of diisopropylethyl amine in 10 ml of EtOH were heated at reflux temperature for 2 days. The reaction mixture was concentrated in vacuo and the crude product chromatographed (silica) to obtain the desired product. This procedure was used to prepare examples 101–102.

후처리

  1. temperatureat reflux temperature for 2 days
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. customthe crude product chromatographed (silica)

출처 및 근거

ORD 기록
ord-ee9773061a0943b58a1861525ed730a9
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07189720B2

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