Azobisisobutyronitrile → 2-(4-Bromomethylphenyl)pyridine

HRID 458510노트

반응식

HRID 458510 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=1.[Br:14]N1C(=O)CCC1=O.N(C(C)(C)C#N)=NC(C)(C)C#N>ClC(Cl)(Cl)Cl>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[CH:9][C:10]([CH2:13][Br:14])=[CH:11][CH:12]=1

참가 물질

5

반응물 3

HCID 6547AzobisisobutyronitrileHCID 67184N-bromobutanimideHCID 782192-(p-Tolyl)pyridine

생성물 1

HCID 98875912-(4-Bromomethylphenyl)pyridine

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

4-(2-Pyridyl)toluene, 2 mL (1.98 g, 11.7 mmol), N-bromosuccinimide (NBS), 2.5 g (14.0 mmol), and α,α′-azobis(isobutyronitrile) (AIBN), 23 mg (0.14 mmol) were suspended in 35 mL tetrachloromethane, and refluxed for 24 hours. The product was filtered, and the solvent removed from the filtrate by rotary evaporation. Equal amounts of chloroform and water were added and the product extracted. The chloroform layer was separated and dried, and the solvent removed. 4-(2-Pyridyl)benzyl bromide, 2 g, was obtained as a sticky yellow solid.

후처리

  1. temperaturerefluxed for 24 hours
  2. filtrationThe product was filtered
  3. customthe solvent removed from the filtrate by rotary evaporation
  4. additionEqual amounts of chloroform and water were added
  5. extractionthe product extracted
  6. customThe chloroform layer was separated
  7. customdried
  8. customthe solvent removed

출처 및 근거

ORD 기록
ord-aebe37f25c0e45598e5623c14797471c
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07192918B2

반응 노트

불러오는 중…