Tetrahydrofuran → HCID 22637025, 화합물

HRID 459841

반응식

Br[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[C:4](Cl)[CH:3]=1.C([Li])CCC.CCCCCC.[B:22]([O:27]C)([O:25]C)[O:23]C.C1C[O:32][CH2:31]C1>>[CH3:31][O:32][C:4]1[CH:3]=[C:2]([O:27][B:22]([OH:23])[OH:25])[CH:7]=[CH:6][C:5]=1[O:8][CH3:9]

참가 물질

반응물 4

HCID 8028Tetrahydrofuran

HCID 8470Trimethyl borate

HCID 30165374-Bromo-2-chloroanisole

HCID 178418244HCID 178418244, 화합물

생성물 1

HCID 22637025HCID 22637025, 화합물

실험 절차

To a THF solution of 4-bromo-2-chloroanisole was added an n-butyllithium/n-hexane solution at −78° C., followed by 30 minutes of stirring. Then, trimethyl borate was added and the whole was warmed to room temperature, followed by 30 minutes of stirring. Using the residue obtained by evaporation of the solvent instead of 3,4-dimethoxyphenylboric acid, an objective compound was obtained in a similar manner to Reference Example 1.

후처리

waitfollowed by 30 minutes
stirringof stirring

출처 및 근거

ORD 기록: ord-1115ae46fc4c4112a137d8b25c599060
출처 데이터셋: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07196080B2

연결된 노트

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