Water → 3-amino-5-(4-fluorophenyl)thiophene-2-carboxylic Acid
반응식
[NH2:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=2)[S:4][C:3]=1[C:14]([O:16]C)=[O:15].[OH-].[Li+].O.C1COCC1>CO>[NH2:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:8]=[CH:9][C:10]([F:13])=[CH:11][CH:12]=2)[S:4][C:3]=1[C:14]([OH:16])=[O:15]참가 물질
6
실험 절차
The mixture consisting of 500 mg of methyl 3-amino-5-(4-fluorophenyl)thiophene-2-carboxylate, 160 mg of lithium hydroxide, 2 ml of water, 2 ml of THF and 2 ml of methanol is stirred at RT for 3 days. After dilution with 15 ml of water, unhydrolyzed ester is removed by extraction with ethyl acetate. The aqueous phase is adjusted to pH 5 using hydrochloric acid and stirred, and the precipitated solid is filtered off with suction and dried.
후처리
- customAfter dilution with 15 ml of water, unhydrolyzed ester is removed by extraction with ethyl acetate
- stirringstirred
- filtrationthe precipitated solid is filtered off with suction
- customdried
출처 및 근거
- ORD 기록
- ord-2c96ff4f637f4338b0e2cb3a6cd9e194
- 출처 데이터셋
- uspto-grants-2007_03
- 특허 번호
- US07196114B2
반응 노트
불러오는 중…