Diphenyl carbonate → N-[2-Methyl-3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carboxamide

HRID 4604

반응식

HRID 4604 반응식
[CH3:1][CH:2]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([CH2:13][N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[CH:8]=1)[CH2:3][NH2:4].C1(O[C:27](=[O:35])OC2C=CC=CC=2)C=CC=CC=1.O.[NH2:37][NH2:38]>C(O)C>[CH3:1][CH:2]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([CH2:13][N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[CH:8]=1)[CH2:3][NH:4][C:27]([NH:37][NH2:38])=[O:35]

참가 물질

5

반응물 3

HCID 7597Diphenyl carbonateHCID 24654Hydrazine hydrate (1:1)HCID 137906092-Methyl-3-[3-(1-piperidinylmethyl)phenoxy]-1-propanamine

생성물 1

HCID 13657331N-[2-Methyl-3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carboxamide

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2.2 g (8 mmol) of 2-methyl-3-[3-(1-piperidinylmethyl)phenoxy]-1-propanamine in 20 ml of ethanol are stirred together with 1.9 g (8 mmol) of diphenylcarbonate at room temperature for 12 hours. 4 g of hydrazine hydrate is then added to the solution and the reaction mixture is heated under reflux for one hour. Isolation of the product is carried out as described in Example 1.

후처리

  1. temperaturethe reaction mixture is heated
  2. temperatureunder reflux for one hour

출처 및 근거

ORD 기록
ord-1a0aab0702614837a64963489ec21c3d
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04727081

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