Hydrochloric Acid → 2-Methyl-3-hydroxy-4-mercaptomethyl-5-vinylpyridine
반응식
[CH3:1][C:2]1[C:7]([OH:8])=[C:6]([CH2:9][S:10]C(=O)C2C=CC=CC=2)[C:5]([CH:19]=[CH2:20])=[CH:4][N:3]=1.[OH-].[Na+].Cl.C(=O)(O)[O-].[Na+]>O1CCCC1>[CH3:1][C:2]1[C:7]([OH:8])=[C:6]([CH2:9][SH:10])[C:5]([CH:19]=[CH2:20])=[CH:4][N:3]=1참가 물질
6
실험 절차
A mixture of 1 g. of 2-methyl-3-hydroxy-4-benzoylthiomethyl-5-vinylpyridine, 10 ml. of tetrahydrofuran, and 10 ml. of 2.5 N aqueous sodium hydroxide was aged at room temperature overnight. The solution was acidified to about pH 6 with hydrochloric acid and then adjusted to pH 7.5 with solid sodium bicarbonate. The mixture was extracted with 3 × 100 ml. of ethyl acetate: isopropanol (9:1 v/v). The extract was dried over magnesium sulfate and concentrated to give 2-methyl-3-hydroxy-4-mercaptomethyl-5-vinylpyridine.
후처리
- additionA mixture of 1 g
- extractionThe mixture was extracted with 3 × 100 ml
- dry with materialThe extract was dried over magnesium sulfate
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-600f1e48f8764fcfb022ff12608b6471
- 출처 데이터셋
- uspto-grants-1977_12
- 특허 번호
- US04061759
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