Hydrochloric Acid → HCID 22760436, 화합물

HRID 461193노트

반응식

HRID 461193 반응식
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([S:12](=[O:17])(=[O:16])[N:13]([CH3:15])[CH3:14])[CH:6]=1)=[O:4].[BH4-].[Na+].Cl>CO>[Br:1][CH2:2][CH:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([S:12](=[O:16])(=[O:17])[N:13]([CH3:14])[CH3:15])[CH:6]=1)[OH:4]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 204768462-Bromo-4'-chloro-3'-dimethylsulfamoylacetophenone

생성물 1

HCID 22760436HCID 22760436, 화합물

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

To a solution of 6.4 g of 2-bromo-4'-chloro-3'-dimethylsulfamoylacetophenone in 28 ml of methanol were added dropwise, at a reaction temperature of 5° C, a solution of 0.6 g of sodium borohydride in 5 ml of methanol and the solution was then stirred for 1 hour at room temperature. The reaction mixture was acidified while cooling (+5° C) with 2 N HCl and the solvent was distilled off under reduced pressure. After adding 70 ml of water, extraction followed with 200 ml of diethyl ether, the organic phase was dried over sodium sulfate, the solvent was distilled off and 2-bromo-1-(4-chloro-3-dimethylsulfamoylphenyl)-ethanol was obtained as fair yellow to colorless oil.

후처리

  1. distillationthe solvent was distilled off under reduced pressure
  2. additionAfter adding
  3. extraction70 ml of water, extraction
  4. dry with materialthe organic phase was dried over sodium sulfate
  5. distillationthe solvent was distilled off

출처 및 근거

ORD 기록
ord-5385b662ef2049898848fabaecbbb030
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04061761

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