Dimethyl Sulfoxide → 7,8-Dichloro-1-methylisoquinoline

HRID 461501노트

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HRID 461501 반응식
[Cl:1][C:2]1[C:11]([Cl:12])=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[CH:9]2)=[CH:4][CH:3]=1.[H-].[Na+].O.[CH3:16]S(C)=O>>[Cl:1][C:2]1[C:11]([Cl:12])=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[C:9]2[CH3:16])=[CH:4][CH:3]=1

참가 물질

5

반응물 4

HCID 679Dimethyl Sulfoxide2회HCID 962Water2회HCID 24758Sodium hydrideHCID 125950627,8-Dichloroisoquinoline

생성물 1

HCID 213938347,8-Dichloro-1-methylisoquinoline

반응 조건

온도
70 °C

실험 절차

Alternatively, 7,8-dichloro-1-methylisoquinoline is prepared by the following procedure. 7,8-Dichloroisoquinoline (0.019 mole) in 100 ml. of dimethylsulfoxide is added to a solution of sodium hydride (0.11 mole) in 100 ml of dimethylsulfoxide at 70° C. The reaction mixture is stirred at 70° C. for four hours under a nitrogen atmosphere. The reaction mixture is cooled, 100 ml. of water is added, and the mixture is poured into 1500 ml. of water. The aqueous mixture is extracted with benzene. The extract is washed, dried over sodium sulfate and evaporated to give 7,8-dichloro-1-methylisoquinoline.

후처리

  1. customAlternatively, 7,8-dichloro-1-methylisoquinoline is prepared by the following procedure
  2. temperatureThe reaction mixture is cooled
  3. additionthe mixture is poured into 1500 ml
  4. extractionThe aqueous mixture is extracted with benzene
  5. washThe extract is washed
  6. dry with materialdried over sodium sulfate
  7. customevaporated

출처 및 근거

ORD 기록
ord-53383e55b9544eaba84b3df80e117137
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04062961

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