Acetic Acid → Orotic Acid

반응식

Cl[C:2](Cl)(Cl)[C:3](Cl)=[O:4].ClC(Cl)(Cl)C(=O)CC(Cl)=O.[NH2:18][C:19]([NH2:21])=[O:20].[C:22]([OH:25])(=[O:24])[CH3:23]>>[C:22]([OH:25])(=[O:24])[C:23]1[NH:21][C:19](=[O:20])[NH:18][C:3](=[O:4])[CH:2]=1

참가 물질

반응물 4

HCID 176Acetic Acid

HCID 1176Urea

HCID 6420Trichloroacetyl chloride

HCID 213917244,4,4-Trichloro-3-oxobutanoyl chloride

생성물 1

HCID 967Orotic Acid

실험 절차

To recap, this invention involves: converting trichloroacetyl chloride with ketone to γ,γ ,γ -trichloroacetoacetyl chloride, adding the reaction mixture to urea dissolved in a polar organic solvent, e.g., acetic acid; evaporating out the resulting 6-trichloromethyluracil; and hydrolyzing the 6-trichloromethyluracil to form orotic acid.