Tert-Butylamine → 2-(2-t-Butylamino-5-thiadiazolyl)-1-methyl-5-nitroimidazole

HRID 462239

반응식

HRID 462239 반응식
[CH:1]1([NH:7][N:8]2[NH:12][CH:11]=[C:10]([C:13]3[N:14]([CH3:21])[C:15]([N+:18]([O-:20])=[O:19])=[CH:16][N:17]=3)[S:9]2)[CH2:6]CCC[CH2:2]1.[C:22](N)(C)(C)C.C1(N)CCCCC1>>[C:1]([NH:7][N:8]1[NH:12][CH:11]=[C:10]([C:13]2[N:14]([CH3:21])[C:15]([N+:18]([O-:20])=[O:19])=[CH:16][N:17]=2)[S:9]1)([CH3:2])([CH3:6])[CH3:22]

참가 물질

4

반응물 3

HCID 6385Tert-ButylamineHCID 7965CyclohexylamineHCID 213908612-(2-Cyclohexylamino-5-thiadiazolyl)-1-methyl-5nitroimidazole

생성물 1

HCID 213908062-(2-t-Butylamino-5-thiadiazolyl)-1-methyl-5-nitroimidazole

실험 절차

The preparation of the above compound is accomplished essentially by the procedure described for the 2-cyclohexylamino derivative (Example 38), an equivalent of t-butylamine replacing the cyclohexylamine. Recrystallization of the crude product from a mixture of ethyl acetate and acetone gives the pure compound melting at 249°-251° C.

후처리

  1. customThe preparation of the above compound
  2. customRecrystallization of the crude product
  3. additionfrom a mixture of ethyl acetate and acetone

출처 및 근거

ORD 기록
ord-73ab2a9a9569489d90ea3ede1479815f
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04065567

연결된 노트

불러오는 중…