5-Methoxy-2-nitrobenzaldehyde → (2-Amino-5-methoxyphenyl)methanol

HRID 463059

반응식

HRID 463059 반응식
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N+:11]([O-])=O)=[C:7]([CH:10]=1)[CH:8]=[O:9].[H][H]>CO.[Ni]>[NH2:11][C:6]1[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:10][C:7]=1[CH2:8][OH:9]

참가 물질

5

반응물 2

HCID 2303715-Methoxy-2-nitrobenzaldehydeHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 13756678(2-Amino-5-methoxyphenyl)methanol

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

A quantity of 181.2 gm (1 mol) of 5-methoxy-2-nitrobenzaldehyde (prepared by methylation of 2-nitro-5-hydroxy-benzaldehyde with methyl iodide/potassium tert.-butoxide in dimethylsulfoxide) is dissolved in 1.8 liters of methanol, mixed with 50 gm of Raney nickel, and hydrogenated at ambient temperature and at 5 bar. After ten hours, the hydrogen uptake has ended. The catalyst is removed by suction filtration, and the methanol is distilled off.

후처리

  1. customhydrogenated at ambient temperature
  2. waitAfter ten hours
  3. customThe catalyst is removed by suction filtration
  4. distillationthe methanol is distilled off

출처 및 근거

ORD 기록
ord-03aee2ce438b454aa75f4a46a9749cfa
출처 데이터셋
uspto-grants-1985_05
특허 번호
US04518597

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