Sodium Hydroxide → 1-(4-Amino-3-benzoylphenyl)ethan-1-one

HRID 463488노트

반응식

HRID 463488 반응식
[NH2:1][C:2]1[CH:15]=[CH:14][C:13]([C:16]2([CH3:21])OCC[O:17]2)=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].Cl(O)(=O)(=O)=O.[OH-].[Na+]>C(O)C>[C:16]([C:13]1[CH:14]=[CH:15][C:2]([NH2:1])=[C:3]([CH:12]=1)[C:4]([C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)=[O:5])(=[O:17])[CH3:21]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 24247Perchloric AcidHCID 21828105[2-Amino-5-(2-methyl-1,3-dioxolan-2-yl)phenyl](phenyl)methanone

생성물 1

HCID 132971931-(4-Amino-3-benzoylphenyl)ethan-1-one수율 93.3%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2-Amino-5-(2-methyl-1,3-dioxolan-2-yl)benzophenone (1.0 g, 3.54 mmol) was dissolved in 30 ml absolute ethanol. To this was added 1M perchloric acid (14 ml). The resulting mixture was stirred at room temperature for 18 hrs. The mixture was made basic with 3N sodium hydroxide solution and then extracted with several portions of methylene chloride. The combined methylene chloride extracts were washed with water, dried with anhydrous sodium sulfate, and evaporated to yield a yellow product (0.79 g) of mp. 158°-161° C. A portion of the product was recrystallized from a mixture of methylene chloride and hexane to yield material of mp. 158°-162° C.

후처리

  1. extractionextracted with several portions of methylene chloride
  2. washThe combined methylene chloride extracts were washed with water
  3. dry with materialdried with anhydrous sodium sulfate
  4. customevaporated

출처 및 근거

ORD 기록
ord-b35946f6cbbc4a0598018d04b45944b4
출처 데이터셋
uspto-grants-1985_05
특허 번호
US04519937

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