Hydrochloric Acid → 2-(2-Mesylamino-1,3-thiazol-4-yl)glyoxylic acid

HRID 463853

반응식

HRID 463853 반응식
[S:1]([NH:5][C:6]1[S:7][CH:8]=[C:9]([C:11](=[O:17])[C:12]([O:14]CC)=[O:13])[N:10]=1)([CH3:4])(=[O:3])=[O:2].[OH-].[Na+].Cl>O>[S:1]([NH:5][C:6]1[S:7][CH:8]=[C:9]([C:11](=[O:17])[C:12]([OH:14])=[O:13])[N:10]=1)([CH3:4])(=[O:2])=[O:3]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 19978726Ethyl 2-(2-mesylamino-1,3-thiazol-4-yl)glyoxylate

생성물 1

HCID 199787632-(2-Mesylamino-1,3-thiazol-4-yl)glyoxylic acid수율 81.3%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Ethyl 2-(2-mesylamino-1,3-thiazol-4-yl)glyoxylate (13.9 g.) was added with stirring at ambient temperature to a solution of sodium hydroxide (5.0 g.) in water (150 ml.). The mixture was stirred for 1 hour at ambient temperature, adjusted to pH 7 with conc. hydrochloric acid and washed with ethyl acetate. The aqueous layer was adjusted to pH 0.5 with conc. hydrochloric acid to precipitate yellow crystals. The crystals were collected by filtration, washed with water and dried to give 2-(2-mesylamino-1,3-thiazol-4-yl)glyoxylic acid (10.16 g.).

후처리

  1. washwashed with ethyl acetate
  2. customto precipitate yellow crystals
  3. filtrationThe crystals were collected by filtration
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-440525bb00a24152a62c851541159c49
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04544653

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