Hydrochloric Acid → 4-Methoxybenzenecarbothioamide

HRID 463884

반응식

HRID 463884 반응식
[C:1](#[N:10])[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][CH:3]=1.C(N)(=[S:13])C.Cl>CN(C)C=O>[CH3:9][O:8][C:5]1[CH:6]=[CH:7][C:2]([C:1]([NH2:10])=[S:13])=[CH:3][CH:4]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 701294-MethoxybenzonitrileHCID 2723949Thioacetamide

생성물 1

HCID 7368274-Methoxybenzenecarbothioamide수율 75.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 53.26 g of anisonitrile and 60.10 g of thioacetamide in 600 ml of dimethylformamide was saturated with dry hydrogen chloride gas while being cooled in an ice bath. The mixture was then distilled on an oil bath at 100° C. After the liquid had been removed, aqueous sodium bicarbonate was added and the solid was collected and recrystallized from toluene, giving 50.47 g of 4-methoxythiobenzamide as a yellow solid.

후처리

  1. temperaturewhile being cooled in an ice bath
  2. distillationThe mixture was then distilled on an oil bath at 100° C
  3. customAfter the liquid had been removed
  4. additionaqueous sodium bicarbonate was added
  5. customthe solid was collected
  6. customrecrystallized from toluene

출처 및 근거

ORD 기록
ord-e79458266d034204a700be91ab1937be
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04544759

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