Hydrochloric Acid → 3-Chloro-5-(trifluoromethyl)pyridin-2-ol

HRID 464130

반응식

HRID 464130 반응식
Cl[C:2]1[C:7]([Cl:8])=[CH:6][C:5]([C:9]([F:12])([F:11])[F:10])=[CH:4][N:3]=1.[OH-:13].[K+].Cl>C(O)(C)(C)C>[Cl:8][C:7]1[C:2](=[O:13])[NH:3][CH:4]=[C:5]([C:9]([F:12])([F:11])[F:10])[CH:6]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 1122342,3-Dichloro-5-(trifluoromethyl)pyridine

생성물 1

HCID 7254363-Chloro-5-(trifluoromethyl)pyridin-2-ol수율 75.3%

시약·촉매·용매 1

HCID 6386tert-Butanol용매

실험 절차

4.5 g of 2,3-dichloro-5-trifluoromethylpyridine was added to a solution of 2.7 g of potassium hydroxide dissolved in 40 ml of t-butanol, and the mixture was reacted at the reflux temperature for one hour while stirring. After completion of the reaction, the reaction product was allowed to cool and made acidic with concentrated hydrochloric acid. The contents were concentrated under reduced pressure to obtain a solid which was then purified to obtain 3.1 g of the titled compound having a melting point of 165° to 166° C.

후처리

  1. customthe mixture was reacted at the reflux temperature for one hour
  2. customAfter completion of the reaction
  3. temperatureto cool
  4. concentrationThe contents were concentrated under reduced pressure
  5. customto obtain a solid which
  6. customwas then purified

출처 및 근거

ORD 기록
ord-3a6e9ed31a844b1ba572167156dce05f
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04546191

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