Hydrochloric Acid → 3-Chloro-5-nitro-2(1H)-pyridinone

HRID 464624

반응식

HRID 464624 반응식
[N+:1]([C:4]1[CH:5]=[CH:6][C:7](=[O:10])[NH:8][CH:9]=1)([O-:3])=[O:2].Cl.[Cl:12]([O-])(=O)=O.[K+]>O>[Cl:12][C:6]1[C:7](=[O:10])[NH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 794535-Nitropyridin-2-olHCID 6426889Potassium Chlorate

생성물 1

HCID 3362893-Chloro-5-nitro-2(1H)-pyridinone

시약·촉매·용매 1

HCID 962Water용매

실험 절차

5-Nitro-2-pyridone (Aldrich Chemical Company) (100 g, 0.71 mol) was added to 1 liter conc. HCl at room temperature, followed by the dropwise addition of a solution of potassium chlorate (87.5 g, 0.71 mol) in 1.2 liter water. A solid material formed during the addition. The mixture was stirred overnight, filtered, and the collected material recrystallized from 50 percent aqueous ethanol. The yield was 77.2 g, 62 percent, m.p. 196°-198° C.

후처리

  1. customA solid material formed during the addition
  2. filtrationfiltered
  3. customthe collected material recrystallized from 50 percent aqueous ethanol

출처 및 근거

ORD 기록
ord-14f5395969a04bf0b5ae561b9969b5b2
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04548888

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