Dimethyl Sulfoxide → 5-Nitro-2-(2,2,2-trifluoroethoxy)pyridine
반응식
Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.[F:11][C:12]([F:16])([F:15])[CH2:13][OH:14].[OH-].[Li+].CS(C)=O>O>[F:11][C:12]([F:16])([F:15])[CH2:13][O:14][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1참가 물질
6
실험 절차
2-Chloro-5-nitropyridine (9.5 grams), 2,2,2-trifluoroethanol (6.0 grams), and lithium hydroxide (4.0 grams) were mixed in 50 ml. of DMSO and stirred overnight (about 18 hours) at room temperature. The reaction mixture was then poured into water and the product was separated by filtration. It was crystallized from ethyl acetate-hexanes, yield 5.0 grams, m.p., 35°-37° C.
후처리
- customthe product was separated by filtration
- customIt was crystallized from ethyl acetate-hexanes, yield 5.0 grams
- custom35°-37° C.
출처 및 근거
- ORD 기록
- ord-558bb867ab5c4bd4a3b4e2b03e7cc939
- 출처 데이터셋
- uspto-grants-1979_11
- 특허 번호
- US04173639
반응 노트
불러오는 중…