Nitromethane → Methyl 3-(4-chlorophenyl)-4-nitrobutanoate
반응식
[Cl:1][C:2]1[CH:13]=[CH:12][C:5]([CH:6]=[CH:7][C:8]([O:10][CH3:11])=[O:9])=[CH:4][CH:3]=1.[N+:14]([CH3:17])([O-:16])=[O:15].CN(C)C(=N)N(C)C>C(OCC)C.Cl>[CH3:11][O:10][C:8](=[O:9])[CH2:7][CH:6]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:13][CH:12]=1)[CH2:17][N+:14]([O-:16])=[O:15]참가 물질
6
실험 절차
A mixture of 290 g of p-chlorocinnamic acid, methyl ester, 500 g of nitromethane and 39 g of tetramethylguanidine is allowed to stir for 72 hours. The solution is diluted with ethyl ether and aqueous hydrochloric acid solution (1 N, 1 liter) is added. The organic layer is separated, dried over anhydrous magnesium sulfate, and evaporated to give 4-nitro-3-(4-chlorophenyl)butanoic acid methyl ester.
후처리
- additionis added
- customThe organic layer is separated
- dry with materialdried over anhydrous magnesium sulfate
- customevaporated
출처 및 근거
- ORD 기록
- ord-e8769266aa604824bfe4c0763b4a3ee2
- 출처 데이터셋
- uspto-grants-1985_10
- 특허 번호
- US04548947
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