Hydrogen Bromide → 1-Methyl-3-bromopropyldimethylamine hydrobromide

HRID 464814노트

반응식

HRID 464814 반응식
[CH3:1][CH:2]([N:12]([CH3:14])[CH3:13])[CH2:3][CH2:4]OC1C=CC=CC=1.[BrH:15]>C(Cl)(Cl)Cl>[BrH:15].[CH3:1][CH:2]([N:12]([CH3:14])[CH3:13])[CH2:3][CH2:4][Br:15]

참가 물질

4

반응물 2

HCID 260Hydrogen BromideHCID 201358801-Methyl-3-phenoxypropyldimethylamine

생성물 1

HCID 201357911-Methyl-3-bromopropyldimethylamine hydrobromide수율 79%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

5 g of the 1-methyl-3-phenoxypropyldimethylamine thus obtained was reacted with 30 ml of 40% hydrobromic acid at 150° C. for 7 hours with stirring. The reaction solution was cooled, 20 ml of chloroform was added and then the solution was separated. The hydrobromic acid was removed under reduced pressure and the residue was recrystallized from 5 ml of ethyl alcohol to give 4.46 g of 1-methyl-3-bromopropyldimethylamine hydrobromide in a yield of 79%.

후처리

  1. temperatureThe reaction solution was cooled
  2. customthe solution was separated
  3. customThe hydrobromic acid was removed under reduced pressure
  4. customthe residue was recrystallized from 5 ml of ethyl alcohol

출처 및 근거

ORD 기록
ord-6727691cc5044cdcafc508eb63de3275
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04549023

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