Bromine → 2-Bromo-1-(3,4-difluorophenyl)ethan-1-one

HRID 46555

반응식

HRID 46555 반응식
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([F:10])=[C:6]([F:11])[CH:5]=1)=[O:3].BrBr.ClC1C=C(Cl)C=CC=1C(=O)C[Br:19].C(C1C=CC=CC=1C(=O)CBr)C.C(C1C=CC(C(=O)CBr)=CC=1)(C)C.C(C1C=C(C=CC=1)C(=O)CBr)C(C)C.CC1C=C(C=CC=1C)C(=O)CBr.C(OC1C=C(C=CC=1)C(=O)CBr)C.C(OC1C=CC(C(=O)CBr)=CC=1)(C)C.C(OC1C=C(C=CC=1OCC)C(=O)CBr)C.FC1C=CC(F)=CC=1C(=O)CBr>C(Cl)(Cl)Cl.C(O)(=O)C>[F:11][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][C:7]=1[F:10])[C:2](=[O:3])[CH2:1][Br:19]

참가 물질

14

반응물 11

HCID 24408BromineHCID 758282-Bromo-1-(2,4-dichlorophenyl)ethan-1-oneHCID 1230521-(3,4-Difluorophenyl)ethan-1-oneHCID 27782642-Bromo-1-(2,5-difluorophenyl)ethanoneHCID 34921042-Bromo-1-(3,4-diethoxyphenyl)ethan-1-oneHCID 37031132-Bromo-1-(3,4-dimethylphenyl)ethan-1-oneHCID 140427562-Bromo-1-(4-(propan-2-yl)phenyl)ethan-1-oneHCID 154539122-Bromo-1-(4-(propan-2-yloxy)phenyl)ethan-1-oneHCID 20387511m-Isobutylphenacyl bromideHCID 226410062-Bromo-1-(3-ethoxyphenyl)ethanoneHCID 234426012-Bromo-1-(2-ethylphenyl)ethan-1-one

생성물 1

HCID 27370322-Bromo-1-(3,4-difluorophenyl)ethan-1-one

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 6212Chloroform용매

실험 절차

To a solution of 10.1 g. (0.065 mole) of 3,4-difluoroacetophenone in 100 ml. of glacial acetic acid was added 3.4 ml. (0.065 mole) of bromine dropwise. When the addition was complete the solution was stirred for 0.5 hr. and then stripped to dryness under reduced pressure. The residue was dissolved in chloroform and washed with aqueous sodium bicarbonate. Evaporation of the organic phase provided 14.8 g. (97%) of colorless liquid product. Similarly prepared were 2,4-dichlorophenacyl bromide, o-ethylphenacyl bromide, p-isopropylphenacyl bromide, m-isobutylphenacyl bromide, 3,4-dimethylphenacyl bromide, m-ethoxyphenacyl bromide, p-isopropoxyphenacyl bromide, 3,4-diethoxyphenacyl bromide, and 2,5-difluorophenacyl bromide.

후처리

  1. additionWhen the addition
  2. washwashed with aqueous sodium bicarbonate
  3. customEvaporation of the organic phase
  4. customprovided 14.8 g
  5. customSimilarly prepared

출처 및 근거

ORD 기록
ord-51ac15fa7aa84ece864078149c112857
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04173650

연결된 노트

불러오는 중…