tert-Butanol → N-boc-4-chlorobenzenesulfonamide

HRID 465621

반응식

HRID 465621 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]=[C:12]=[O:13])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[C:14]([OH:18])([CH3:17])([CH3:16])[CH3:15]>>[C:14]([O:18][C:12]([NH:11][S:8]([C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)(=[O:9])=[O:10])=[O:13])([CH3:17])([CH3:16])[CH3:15]

참가 물질

3

반응물 2

HCID 6386tert-ButanolHCID 1385874-Chlorobenzenesulfonyl isocyanate

생성물 1

HCID 14796817N-boc-4-chlorobenzenesulfonamide

실험 절차

The commercially available p-chlorophenylsulfonyl isocyanate (15.0 g, 58.6 mmol) is added dropwise to t-butanol (90 ml) and the mixture is allowed to stir at room temperature for 60 hours. The solvent is evaporated and the white solid is recrystallized from hexane and ethylacetate to obtain N-t-butoxycarbonyl-p-chlorophenylsulfonamide, m.p. 98°-99° C.

후처리

  1. customThe solvent is evaporated
  2. customthe white solid is recrystallized from hexane and ethylacetate

출처 및 근거

ORD 기록
ord-c6fefe3fbe4c4b8ba246ce545c3a9649
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05153214

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