Benzylamine → N-[2,6-bis(1-methylethyl)phenyl]-2-[phenylmethyl]amino-acetamide

HRID 465655

반응식

HRID 465655 반응식
Br[CH2:2][C:3](Br)=[O:4].[CH:6]([C:9]1[CH:15]=[CH:14][CH:13]=[C:12]([CH:16]([CH3:18])[CH3:17])[C:10]=1[NH2:11])([CH3:8])[CH3:7].[CH2:19]([NH2:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C(N(CC)CC)C>[CH3:17][CH:16]([C:12]1[CH:13]=[CH:14][CH:15]=[C:9]([CH:6]([CH3:8])[CH3:7])[C:10]=1[NH:11][C:3](=[O:4])[CH2:2][NH:26][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH3:18]

참가 물질

5

반응물 3

HCID 7504BenzylamineHCID 32484DiisopropylanilineHCID 61147Bromoacetyl bromide

생성물 1

HCID 19764427N-[2,6-bis(1-methylethyl)phenyl]-2-[phenylmethyl]amino-acetamide수율 96%

시약·촉매·용매 1

HCID 8471Triethylamine용매2회

실험 절차

Bromoacetylbromide (4.5 mL) was added portionwise to a mixture of 8.85 g 2,6-diisopropylaniline and 7.0 mL triethylamine in 300 mL EtoAc at 0° C. Upon completing the addition, excess triethylamine and 5.4 g benzylamine were added and the entire mixture was heated on the steambath for 30 minutes. The reaction mixture was allowed to sit overnight at room temperature, and was then filtered, concentrated, and filtered through silica gel (70-230 mesh) using hexane/EtoAc, 1/1, as eluant. A total of 15.62 g (96%) of the title product was obtained.

후처리

  1. additionwere added
  2. temperaturethe entire mixture was heated on the steambath for 30 minutes
  3. filtrationwas then filtered
  4. concentrationconcentrated
  5. filtrationfiltered through silica gel (70-230 mesh)

출처 및 근거

ORD 기록
ord-6a16c88ba0b2498c9f6d4e1a74c93659
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05153226

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