Hydrochloric Acid → 6-ethoxy-9H-purin-2-amine

HRID 465712

반응식

HRID 465712 반응식
[Na].[CH2:2]([OH:4])[CH3:3].[NH2:5][C:6]1[N:14]=[C:13]2[C:9]([NH:10][CH:11]=[N:12]2)=[C:8](Cl)[N:7]=1.Cl>O>[NH2:5][C:6]1[N:14]=[C:13]2[C:9]([NH:10][CH:11]=[N:12]2)=[C:8]([O:4][CH2:2][CH3:3])[N:7]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 53603492-Amino-6-chloropurineHCID 5360545Sodium

생성물 1

HCID 958056-ethoxy-9H-purin-2-amine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Sodium (0.68 g, 29.5 mmol, Aldrich lot #9621CL) was added in portions to anhydrous ethanol (50 mL). Upon complete dissolution 2-amino-6-chloropurine (1 g, 5.9 mmol Sigma lot #69F4064) was added and the reaction heated at reflux for 96 hours. The reaction was cooled, diluted with 20 mL water, and neutralized with 1N HCl. The solvents were evaporated and the residue slurried in 100 mL water. The product was filtered off and air dried to give 0.95 g (5.3 mmol; 89.9%); mp=252-°253° C.

후처리

  1. additionwas added
  2. temperaturethe reaction heated
  3. temperatureat reflux for 96 hours
  4. temperatureThe reaction was cooled
  5. customThe solvents were evaporated
  6. filtrationThe product was filtered off
  7. customair dried
  8. customto give 0.95 g (5.3 mmol; 89.9%)
  9. custommp=252-°253° C.

출처 및 근거

ORD 기록
ord-708ab2843f02454bb1caa62d1a0aa4fa
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05153318

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