Chloromethyl pivalate → Ticlopidine Hydrochloride

HRID 46675

반응식

HRID 46675 반응식
[C:1](OC[Cl:9])(=O)C(C)(C)C.[Cl:10][C:11]1[CH:25]=[CH:24][CH:23]=[CH:22][C:12]=1[CH2:13][NH:14][CH2:15][CH2:16][C:17]1[S:18][CH:19]=[CH:20][CH:21]=1>CS(C)=O>[ClH:9].[Cl:10][C:11]1[CH:25]=[CH:24][CH:23]=[CH:22][C:12]=1[CH2:13][N:14]1[CH2:15][CH2:16][C:17]2[S:18][CH:19]=[CH:20][C:21]=2[CH2:1]1

참가 물질

4

반응물 2

HCID 87885Chloromethyl pivalateHCID 6454012N-((2-chlorophenyl)methyl)thiophene-3-ethylamine

생성물 1

HCID 65335Ticlopidine Hydrochloride수율 51%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

66.5 g (0.44 M) chloromethyl pivalate is reacted by heating, for 3 hours, with a solution of 103 g (0.4 M) N-(2-chloro-benzyl)-2-(2-thienyl)ethylamine in 300 ml dimethylsulfoxide, to give the title compound in a yield of 51%.

출처 및 근거

ORD 기록
ord-e1e3cd2e741d47f5826cb8f92d901749
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04174448

연결된 노트

불러오는 중…