Hydrochloric Acid → Alendronic Acid

반응식

C1(=O)[N:5]([CH2:6][CH2:7][CH2:8][C:9]([P:17](=[O:22])([O:20]C)[O:18]C)([P:11](=[O:16])([O:14]C)[O:12]C)[OH:10])C(=O)C2=CC=CC=C12.Cl>>[NH2:5][CH2:6][CH2:7][CH2:8][C:9]([P:17](=[O:18])([OH:20])[OH:22])([P:11](=[O:12])([OH:14])[OH:16])[OH:10]

참가 물질

반응물 2

HCID 313Hydrochloric Acid

HCID 9845824Tetramethyl phthalimido-1-hydroxybutylidene-bisphosphonate

생성물 1

HCID 2088Alendronic Acid

실험 절차

contacting tetramethyl phthalimido-1-hydroxybutylidene-bisphosphonate from Step (b) with aqueous hydrochloric acid at a temperature range of 80° C. to reflux to form 4-amino-1-hydroxybutylidene-bisphosphonic acid.

후처리

customat a temperature range of 80° C.
temperatureto reflux

출처 및 근거

ORD 기록: ord-1ab92b05e0d34afbb421dd2d7859da8f
출처 데이터셋: uspto-grants-1992_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05159108

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