Sodium Hydroxide → AN-465/43411221

HRID 46774

반응식

HRID 46774 반응식
Br.[CH2:2]([NH:10][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([O:21][CH3:22])[CH:14]=1)[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[OH-].[Na+]>O>[CH2:2]([NH:10][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([O:21][CH3:22])[CH:14]=1)[CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 30486862-(3,4-Dimethoxyphenyl)-N-(2-phenylethyl)ethan-1-amine--hydrogen bromide (1/1)

생성물 1

HCID 215356AN-465/43411221수율 97.5%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
0 °C

실험 절차

25 g of the latter hydrobromide were dissolved in 250 ml of hot water and the solution was cooled to 0° C. and made alkaline with 40 ml of 2 N sodium hydroxide. The mixture was extracted 3 times with 100 ml of ethyl acetate and the organic extracts were washed with water until the wash water had a pH of 7 to 8. The extracts were dried over sodium sulfate, were filtered and evaporated to dryness under reduced pressure to obtain 19 g of N-phenethyl-3,4-dimethoxyphenethylamine.

후처리

  1. extractionThe mixture was extracted 3 times with 100 ml of ethyl acetate
  2. washthe organic extracts were washed with water until the wash water
  3. dry with materialThe extracts were dried over sodium sulfate
  4. filtrationwere filtered
  5. customevaporated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-667f98f9fa514bd293cae9b10b6fc01d
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04175136

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