Hydrochloric Acid → 4-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-2-methyl-2H-pyrazole-3-carboxylic acid

HRID 467769

반응식

HRID 467769 반응식
C([O:3][C:4]([C:6]1[N:7]([CH3:30])[N:8]=[CH:9][C:10]=1[NH:11][C:12]([C:14]1[C:19]([NH:20][C:21]2[CH:22]=[N:23][CH:24]=[N:25][CH:26]=2)=[N:18][CH:17]=[C:16]([CH:27]2[CH2:29][CH2:28]2)[N:15]=1)=[O:13])=[O:5])C.[OH-].[Na+].Cl>C(O)C.O>[CH:27]1([C:16]2[N:15]=[C:14]([C:12]([NH:11][C:10]3[CH:9]=[N:8][N:7]([CH3:30])[C:6]=3[C:4]([OH:5])=[O:3])=[O:13])[C:19]([NH:20][C:21]3[CH:26]=[N:25][CH:24]=[N:23][CH:22]=3)=[N:18][CH:17]=2)[CH2:29][CH2:28]1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 700988464-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester

생성물 1

HCID 700980734-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-2-methyl-2H-pyrazole-3-carboxylic acid수율 95%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

반응 조건

온도
85 °C

실험 절차

To a suspension of 4-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester (1.13 g, 2.77 mmol) in ethanol (15 ml) and water (12 ml) was added 1N NaOH (3.32 ml) at r.t. under argon atmosphere. The yellow suspension was stirred at 85° C. for 1 h. After cooling down to r.t., the mixture was treated with 1M HCl (3.3 ml) and stirred for 30 min. The product was collected by filtration, washed with water and EtOH, and dried to yield a light yellow solid (1.0 g, 95%).

후처리

  1. temperatureAfter cooling down to r.t.
  2. stirringstirred for 30 min
  3. filtrationThe product was collected by filtration
  4. washwashed with water and EtOH
  5. customdried

출처 및 근거

ORD 기록
ord-e15e9bc129d14e1e8597c032c09720b2
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08623866B2

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