Phenylmethyl 4-nitrobenzoate → Benzyl p-aminobenzoate

HRID 467801

반응식

HRID 467801 반응식
[N+:1]([C:4]1[CH:19]=[CH:18][C:7]([C:8]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:9])=[CH:6][CH:5]=1)([O-])=O>O1CCOCC1.[Ni]>[NH2:1][C:4]1[CH:19]=[CH:18][C:7]([C:8]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:9])=[CH:6][CH:5]=1

참가 물질

4

반응물 1

HCID 84647Phenylmethyl 4-nitrobenzoate

생성물 1

HCID 98488Benzyl p-aminobenzoate수율 93.4%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 312751,4-Dioxane용매

실험 절차

20.6 g of the benzyl 4-nitrobenzoate are dissolved in 350 mL dioxane and this solution is combined with 6.9 g (49.9 mmol, 0.61 eq) Raney nickel. The mixture is hydrogenated at 5 bar H2 pressure for 16 h with stirring. The catalyst is filtered off and all the volatile constituents are eliminated in vacuo. 17 g benzyl 4-aminobenzoate are obtained.

후처리

  1. filtrationThe catalyst is filtered off

출처 및 근거

ORD 기록
ord-089e658d436f4ff495a9757f8aaf70de
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08623887B2

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