Hydrochloric Acid → HCID 59625999, 화합물

HRID 468105노트

반응식

HRID 468105 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[N:7]1[CH2:16][CH2:15][C:14]2[C:9](=[C:10]([C:17]([O:19]C)=[O:18])[CH:11]=[CH:12][CH:13]=2)[CH2:8]1.[OH-].[Na+].Cl>C1COCC1>[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[N:7]1[CH2:16][CH2:15][C:14]2[C:9](=[C:10]([C:17]([OH:19])=[O:18])[CH:11]=[CH:12][CH:13]=2)[CH2:8]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 59625970HCID 59625970, 화합물

생성물 1

HCID 59625999HCID 59625999, 화합물수율 311.6%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Compound 9u (187 mg, 0.44 mmol) was refluxed with 3N aqueous NaOH (0.25 mL mg, 0.75 mmol) in THF (6 mL) overnight. Concentrated HCl solution was added to the mixture to adjust pH to 3-4. The resulting mixture was concentrated to give 9v (350 mg) as the tris-HCl salt.

후처리

  1. concentrationThe resulting mixture was concentrated

출처 및 근거

ORD 기록
ord-ac8d35e8e2e04420b4d2ed8b0c3cc816
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08623858B2

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