3-Amino-1-propanol → 3-[(2-Chloro-6-nitrophenyl)amino]-1-propanol

HRID 46853

반응식

HRID 46853 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N+:8]([O-:10])=[O:9])[C:3]=1Cl.[NH2:12][CH2:13][CH2:14][CH2:15][OH:16]>C(O)CCC>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N+:8]([O-:10])=[O:9])[C:3]=1[NH:12][CH2:13][CH2:14][CH2:15][OH:16]

참가 물질

4

반응물 2

HCID 90863-Amino-1-propanolHCID 185552,3-Dichloronitrobenzene

생성물 1

HCID 203855663-[(2-Chloro-6-nitrophenyl)amino]-1-propanol

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

A mixture of 100 parts of 1,2-dichloro-3-nitrobenzene, 95 parts of 3-amino-1-propanol and 200 parts of butanol is stirred and refluxed overnight. The reaction mixture is cooled and evaporated. The residue is taken up in water and the product is extracted with methylbenzene. The extract is washed with water, dried, filtered and evaporated, yielding 115 parts of 3-[(2-chloro-6-nitrophenyl)amino]-1-propanol as a residue.

후처리

  1. temperaturerefluxed overnight
  2. temperatureThe reaction mixture is cooled
  3. customevaporated
  4. extractionthe product is extracted with methylbenzene
  5. washThe extract is washed with water
  6. customdried
  7. filtrationfiltered
  8. customevaporated

출처 및 근거

ORD 기록
ord-3cf7f60be5d04e27a25f57e8e5833753
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04175129

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