Dimethylformamide → HCID 178507935, 화합물

HRID 46952

반응식

HRID 46952 반응식
[Cl:1][C:2]1C=C2C(OC(=O)NC2=[CH:4][CH:3]=1)=O.[C:14](#[N:18])[CH2:15][C:16]#N.C([N:21]([CH2:24][CH3:25])CC)C.CN(C)[CH:28]=[O:29]>Br>[NH2:21][C:24]1[CH:25]=[C:28]([OH:29])[C:15]2[C:14](=[CH:4][CH:3]=[C:2]([Cl:1])[CH:16]=2)[N:18]=1

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 8010MalononitrileHCID 8471TriethylamineHCID 784805-Chloroisatoic anhydride

생성물 1

HCID 178507935HCID 178507935, 화합물

시약·촉매·용매 1

HCID 260Hydrogen Bromide용매

실험 절차

Following the procedure of Example 2, 5-chloroisatoic anhydride (19.8 g., 0.1 mole), malononitrile (7.3 g., 0.11 mole) and triethylamine (11.1 g., 0.11 mole) are reacted together in N,N-dimethylformamide (200 ml.) to give 20 g. of product. Five grams of said product are refluxed for 22 hours in 48% hydrobromic acid (175 ml.) to give 4.2 g. (86%) yield of title product; m.p. 356° C. (dec.).

후처리

  1. customto give 20 g
  2. customto give 4.2 g

출처 및 근거

ORD 기록
ord-b90080cd45e54ad095185fcba285c747
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04175193

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