Carbon tetrabromide → 5-Bromo-2-(bromomethyl)-1,3-difluorobenzene
반응식
[Br:1][C:2]1[CH:9]=[C:8]([F:10])[C:5]([CH2:6]O)=[C:4]([F:11])[CH:3]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:32]>C1COCC1>[Br:1][C:2]1[CH:9]=[C:8]([F:10])[C:5]([CH2:6][Br:32])=[C:4]([F:11])[CH:3]=1참가 물질
5
실험 절차
To a cooled (0° C.) solution of 4 g (17.6 mmol) 4-bromo-2,6-difluorobenzyl alcohol in 50 ml THF, 7 g (26.4 mmol) triphenylphosphine and 8.83 g (26.4 mmol) carbon tetrabromide are added with stirring. Stirring is continued for 10 min at 0° C. and for 1 h at room temperature. After that the reaction mixture is filtered and the filtrate is concentrated in vacuo. The residue is purified by chromatography (silicagel, hexane) to afford the title compound as yellowish oil.
후처리
- additionare added
- stirringStirring
- filtrationAfter that the reaction mixture is filtered
- concentrationthe filtrate is concentrated in vacuo
- customThe residue is purified by chromatography (silicagel, hexane)
출처 및 근거
- ORD 기록
- ord-0d02b1b38e944b19896040d89c32db47
- 출처 데이터셋
- uspto-grants-2014_01
- 특허 번호
- US08629168B2
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