Hydrochloric Acid → 4-Chloro-2-fluoroaniline
반응식
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([NH:6]C(=O)C)=[C:4]([F:12])[CH:3]=1.Cl>C(O)C>[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([NH2:6])=[C:4]([F:12])[CH:3]=1참가 물질
4
실험 절차
A mixture of 119 parts of 4'-chloro-2'-fluoroacetanilide in 475 parts of ethanol and 200 parts of 37% hydrochloric acid was refluxed for 17 hours and the solvent removed at a reduced pressure of 300 mm.Hg to yield the moist, solid hydrochloride salt of 4-chloro-2-fluoroaniline.
후처리
- temperaturewas refluxed for 17 hours
- customthe solvent removed at a reduced pressure of 300 mm.Hg
출처 및 근거
- ORD 기록
- ord-ebdbfc73549c44b5b2abb8ac1aa4e104
- 출처 데이터셋
- uspto-grants-1979_11
- 특허 번호
- US04175948
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