Methanethiol → Ethyl 2-[(methylsulfanyl)methyl]prop-2-enoate

HRID 47131

반응식

HRID 47131 반응식
[CH3:1][SH:2].[Na].[CH2:4]([O:6][C:7](=[O:12])[C:8]([CH2:10]Br)=[CH2:9])[CH3:5]>C(O)C.O>[CH2:4]([O:6][C:7](=[O:12])[C:8]([CH2:10][S:2][CH3:1])=[CH2:9])[CH3:5]

참가 물질

6

반응물 3

HCID 878MethanethiolHCID 3106202-(Bromomethyl)acrylic acid ethyl esterHCID 5360545Sodium

생성물 1

HCID 12463627Ethyl 2-[(methylsulfanyl)methyl]prop-2-enoate

시약·촉매·용매 2

HCID 702Ethanol용매2회HCID 962Water용매

실험 절차

A solution of methylmercaptan (4.8 g.) and sodium (2.3 g.) in absolute ethanol (75 ml.) is added dropwise to a solution of ethyl-2-bromomethylacrylate (19.3 g.) in ethanol (25 ml.). After two hours, it is diluted with water (400 ml.) and extracted with methylene chloride. The organic layer is dried and concentrated to dryness in vacuo to yield ethyl-2-methylthiomethylacrylate.

후처리

  1. extractionextracted with methylene chloride
  2. customThe organic layer is dried
  3. concentrationconcentrated to dryness in vacuo

출처 및 근거

ORD 기록
ord-4a61041afbef48b3896e65e216918e56
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04176235

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